|
|
H+ + 5''-oxoaverantin <=> (1''S,5''S)-averufin + H2O
|
4.2.1.142
5'-oxoaverantin cyclase
|
–
|
| |
BRENDA:
BR50550
KEGG:
R10475
MetaCyc:
RXN-9485
|
|
|
|
S-adenosyl-L-methionine + sterigmatocystin <=> 8-O-methylsterigmatocystin + S-adenosyl-L-homocysteine + H+
|
2.1.1.110
sterigmatocystin 8-O-methyltransferase
|
–
|
| |
BRENDA:
BR43870
KEGG:
R03111
MetaCyc:
2.1.1.110-RXN
|
|
|
|
(1''S)-averantin + NADP+ <=> norsolorinic_acid + NADPH + H+
|
1.1.1.349
norsolorinic acid ketoreductase
1.1.1.B25
|
–
–
|
| |
BRENDA:
BR50499
KEGG:
R10309
MetaCyc:
RXN-9480
|
|
|
|
(1''S)-averantin + reduced_flavodoxin + O2 <=> (1''S,5''R)-5''-hydroxyaverantin + flavin + H2O
|
1.14.14.116
averantin hydroxylase
|
–
|
| |
BRENDA:
BR50522
KEGG:
R10318
|
|
|
|
(1''S,5''R)-hydroxyaverantin + NAD+ <=> H+ + 5''-oxoaverantin + NADH
|
1.1.1.352
5'-hydroxyaverantin dehydrogenase
|
–
|
| |
BRENDA:
BR50503
KEGG:
R10311
MetaCyc:
RXN-9484
|
|
|
|
S-adenosyl-L-methionine + dihydrodemethylsterigmatocystin <=> H+ + dihydrosterigmatocystin + S-adenosyl-L-homocysteine
|
2.1.1.109
demethylsterigmatocystin 6-O-methyltransferase
|
–
|
| |
BRENDA:
BS319593
KEGG:
R10403
MetaCyc:
RXN-9500
|
|
|
|
versiconol + NADP+ <=> versiconal + NADPH
|
1.1.1.353
versiconal hemiacetal acetate reductase
|
–
|
| |
BRENDA:
BR50506
KEGG:
R10400
MetaCyc:
RXN-9491
|
|
|
|
versicolorin_B + O2 + NADPH + H+ <=> Versicolorin_A + NADP+ + 2 H2O
|
not assigned
|
–
|
| |
KEGG:
R10479
|
|
|
|
S-adenosyl-L-methionine + 6-demethylsterigmatocystin <=> H+ + S-adenosyl-L-homocysteine + sterigmatocystin
|
2.1.1.109
demethylsterigmatocystin 6-O-methyltransferase
|
–
|
| |
BRENDA:
BR43868
KEGG:
R03112
MetaCyc:
2.1.1.109-RXN
|
|
|
|
versicolorin_B <=> dihydrodemethylsterigmatocystin
|
not assigned
|
–
|
| |
KEGG:
R10480
MetaCyc:
RXN-9499
|
|
|
|
hexanoyl-[acyl-carrier_protein] + malonyl-CoA + H+ <=> norsolorinic_acid_anthrone + [acyl-carrier_protein] + CoA + CO2 + H2O
|
2.3.1.221
noranthrone synthase
|
–
|
| |
BRENDA:
BR50415
KEGG:
R10239
MetaCyc:
RXN-9479
|
|
|
|
H+ + 1'-hydroxyversicolorone + NADPH + O2 <=> versiconal_hemiacetal_acetate + NADP+ + H2O
|
not assigned
|
–
|
| |
KEGG:
R10477
MetaCyc:
RXN-9487
|
|
|
|
(1''S,5''S)-Averufin + NADPH + H+ + O2 <=> 1''-Hydroxyversicolorone + NADP+ + H2O
|
not assigned
|
–
|
| |
KEGG:
R10476
|
|
|
|
H+ + versicolorone + NADPH + O2 <=> versiconol_acetate + NADP+ + H2O
|
not assigned
|
–
|
| |
KEGG:
R10478
MetaCyc:
RXN-9492
|
|
|
|
ATP + acetyl-CoA + HCO3- <=> ADP + phosphate + malonyl-CoA + H+
|
6.4.1.2
acetyl-CoA carboxylase
6.4.1.3
propionyl-CoA carboxylase
6.4.1.4
methylcrotonoyl-CoA carboxylase
|
–
–
–
|
| |
BRENDA:
BR6444
KEGG:
R00742
MetaCyc:
ACETYL-COA-CARBOXYLTRANSFER-RXN
SABIO-RK:
542
|
|
|
|
versicolorone + NADP+ <=> 1'-hydroxyversicolorone + NADPH
|
1.1.1.353
versiconal hemiacetal acetate reductase
|
–
|
| |
BRENDA:
BR50504
KEGG:
R09756
MetaCyc:
RXN-9489
|
|
|
|
8-O-methylsterigmatocystin + 2 reduced_flavodoxin + 2 O2 <=> aflatoxin_B1 + 2 flavin + H2O + methanol + CO2
|
1.14.14.117
aflatoxin B synthase
|
–
|
| |
BRENDA:
BR50523
KEGG:
R10319
|
|
|
|
versiconal_hemiacetal_acetate + H2O <=> versiconal + acetate
|
3.1.1.94
versiconal hemiacetal acetate esterase
|
–
|
| |
BRENDA:
BR50545
KEGG:
R10401
MetaCyc:
RXN-9488
|
|
|
|
versiconal <=> versicolorin_B + H2O + H+
|
4.2.1.143
versicolorin B synthase
|
–
|
| |
BRENDA:
BR50551;
BS424365;
BS424366
KEGG:
R10402
MetaCyc:
RXN-9494
|
|
|
|
versiconol_acetate + NADP+ <=> versiconal_hemiacetal_acetate + NADPH
|
1.1.1.353
versiconal hemiacetal acetate reductase
|
–
|
| |
BRENDA:
BR50505
KEGG:
R10399
MetaCyc:
RXN-9490
|
|
|
|
S-adenosyl-L-methionine + dihydrosterigmatocystin <=> H+ + 8-O-methyldihydrosterigmatocystin + S-adenosyl-L-homocysteine
|
2.1.1.110
sterigmatocystin 8-O-methyltransferase
|
–
|
| |
BRENDA:
BR50532
KEGG:
R10307
MetaCyc:
RXN-9501
|
|
|
|
versiconol_acetate + H2O <=> versiconol + acetate
|
3.1.1.94
versiconal hemiacetal acetate esterase
|
–
|
| |
BRENDA:
BR50546
KEGG:
R10398
MetaCyc:
RXN-9493
|
|
|
|
8-O-methylsterigmatocystin <=> aflatoxin_G1
|
not assigned
|
–
|
| |
KEGG:
R10483
MetaCyc:
RXN-9498
|
|
|
|
8-O-methyldihydrosterigmatocystin + 2 reduced_flavodoxin + 2 O2 <=> Aflatoxin_B2 + 2 flavin + H2O + methanol + CO2
|
1.14.14.117
aflatoxin B synthase
|
–
|
| |
BRENDA:
BR50524
KEGG:
R10320
|
|
|
|
Versicolorin_A <=> 6-demethylsterigmatocystin
|
not assigned
|
–
|
| |
KEGG:
R10481
|
|
|
|
(1''S)-averantin + reduced_flavodoxin + O2 <=> (1''S,5''S)-5''-hydroxyaverantin + flavin + H2O
|
1.14.14.116
averantin hydroxylase
|
–
|
| |
BRENDA:
BR50521
KEGG:
R10317
|
|
|
|
8-O-methyldihydrosterigmatocystin <=> Aflatoxin_G2
|
not assigned
|
–
|
| |
KEGG:
R10482
MetaCyc:
RXN-9503
|
|
|
|
norsolorinic_acid_anthrone + O2 <=> norsolorinic_acid + H2O
|
1.13.12.20
noranthrone monooxygenase
|
–
|
| |
BRENDA:
BR50371
KEGG:
R10224
MetaCyc:
RXN-11624
|
|
|
|
(1''S,5''S)-hydroxyaverantin + NAD+ <=> H+ + 5''-oxoaverantin + NADH
|
1.1.1.352
5'-hydroxyaverantin dehydrogenase
|
–
|
| |
BRENDA:
BR50502
KEGG:
R10310
MetaCyc:
RXN-9483
|
|
